{"title":"Clinical Trials","description":"","products":[{"product_id":"current-therapeutic-strategies-for-the-management-of-cancer","title":"Current Therapeutic Strategies for the Management of Cancer","description":"\u003cp\u003e\u003cstrong\u003eCurrent Cancer Biomarkers\u003c\/strong\u003e is a comprehensive review on the status of biological markers for various types of cancer. It aims to update readers on current developments on the subject. The contents are divided into 5 sections covering a wide range of biomarkers and their diagnostic applications. The range of tumour biomarkers referenced here gives insights into molecular mechanisms behind cancer, including initiation, development, progression, prognosis, response to the therapeutic modalities, recurrence, and point-of-care application to detect cancer.Key features- Introduction of the basic features of cancer markers- Comprehensive and updated coverage of potential and effective biomarkers including genomic, epigenomic, transcriptomic, proteomic, cellular and morphologic factors- Information on biomarkers in many types of cancers including breast cancer, colorectal cancer, skin cancer, leukemia, liver cancer and prostate cancer- Applications of biomarkers in cancer diagnosis- Structured contents with easy-to-understand sections and headings- References for advanced readersThe updated information about different aspects of cancer markers in the experimental and clinical setting will enrich the reader's understanding of the disease. The information serves as a resource to help in better management of cancer patients and understanding cancer biology when planning medical research projects. The book is intended as a reference for a diverse audience: biomedical science students, medical students, academics, researchers, clinicians and multidisciplinary teams involved in cancer management and research.\u003ci class=\"a-icon a-icon-extender-expand\"\u003e\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003cbr\u003ePublisher: Nova Medicine and Health;\u003cbr\u003eISBN: 9798891131972\u003cbr\u003eISBN: 9798891131330\u003cbr\u003eCopyright: 2023\u003c\/p\u003e","brand":"ReadSpots - Medical Education","offers":[{"title":"Default Title","offer_id":52023210311973,"sku":"RE0081-007","price":34.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0969\/0189\/0341\/files\/9798891131330-1-1000x1519_1.jpg?v=1772194225"},{"product_id":"epigenetic-cancer-therapy-translational-epigenetics-2nd-edition","title":"Epigenetic Cancer Therapy (Translational Epigenetics), 2nd Edition","description":"\u003cp\u003e\u003cstrong\u003eEpigenetic Cancer Therapy, Second Edition \u003c\/strong\u003eprovides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOur knowledge of the plasticity of the epigenome in cancer and disease \u003c\/strong\u003ehas expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR\/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003cbr\u003ePublisher ‏ : ‎ Academic Press; 2nd edition (May 17, 2023)\u003cbr\u003eLanguage ‏ : ‎ English\u003cbr\u003ePaperback ‏ : ‎ 772 pages\u003cbr\u003eISBN-10 ‏ : ‎ 0323913679\u003cbr\u003eISBN-13 ‏ : ‎ 978-0323913676\u003c\/p\u003e","brand":"ReadSpots - Medical Education","offers":[{"title":"Default Title","offer_id":52023210737957,"sku":null,"price":29.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0969\/0189\/0341\/files\/61dptz8A24L._AC_UF1000_1000_QL80.jpg?v=1772196139"},{"product_id":"non-melanoma-skin-cancer-essentials-for-oncologists","title":"Non-melanoma Skin Cancer: Essentials for Oncologists","description":"\u003cp\u003eBy Agata Rembielak, Luca Tagliaferri\u003cbr\u003e\nThis book provides a comprehensive introduction to the current state-of-the-art in skin cancer, exploring the recent developments, appraising the current evidence and providing future directions with particular emphasis on interdisciplinary collaboration and need for clinical trials. It covers all aspects of skin cancers, including epidemiology, pathology, surgical and non-surgical treatments.\u003cbr\u003e\nIt will be a valuable reference for oncologists, dermatologists, dermatopathologists, surgeons, allied health care professionals and other specialists and trainees with a special interest in skin cancer who want to update their knowledge in the multidisciplinary management of such patients. The book will be of interest to medical physicists and radiographers who would like an overview of the current practice in skin cancer. The book can be used by students in medicine, nursing, radiography and medical physics.\u003cbr\u003e\nFeatures\u003cbr\u003e\nProvides a comprehensive review of all aspects of skin cancer management.\u003cbr\u003e\nEdited by experts in the area, with interdisciplinary and international collaborators.\u003cbr\u003e\nPromotes a 'Bigger picture' approach to the topic with multidisciplinary insight.\u003cbr\u003e\nProduct Details\u003cbr\u003e\nPublisher ‏ : ‎ CRC Press; 1st edition (March 16, 2023)\u003cbr\u003e\nLanguage ‏ : ‎ English\u003cbr\u003e\nHardcover ‏ : ‎ 436 pages\u003cbr\u003e\nISBN-10 ‏ : ‎ 103210371X\u003cbr\u003e\nISBN-13 ‏ : ‎ 978-1032103716\u003c\/p\u003e","brand":"ReadSpots - Medical Education","offers":[{"title":"Default Title","offer_id":52023212310821,"sku":null,"price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0969\/0189\/0341\/files\/978-1032103716-9781000832600-103210371X-1003226019-1032127414-9781032103716-9781003226017-9781032127415.jpg?v=1771765858"},{"product_id":"pancreatic-cancer-basic-mechanisms-and-therapies-advances-in-cancer-research-volume-159","title":"Pancreatic Cancer: Basic Mechanisms and Therapies (Advances in Cancer Research, Volume 159)","description":"\u003cp\u003e\u003cstrong\u003ePancreatic Cancer: Basic Mechanisms and Therapies, Volume 159\u003c\/strong\u003e in the Advances in Cancer Research, presents the latest release in this ongoing, well-regarded serial with invaluable information on the exciting and fast-moving field of cancer research.\u003cbr\u003ePancreatic cancer (PC) is the third leading cause of cancer-related deaths in the United States. Greater than 90% PCs are Pancreatic ductal adenocarcinomas (PDAC) which have a dismal estimated 5-year overall survival of only 11%. PDAC is predicted to become the second leading cause of mortality in the United States by 2030. In the clinic, the PDAC patients often present with incurable disease at the time of first diagnosis. This cancer is particularly lethal because of its propensity to spread quickly to distant organs, including the lymphatic system. PDAC metastasis occurs shortly after tumor initiation and is caused by a complex interaction between autonomous tumor cells and cellular elements of the tumor microenvironment. Although PDAC remains a challenging disease to treat and a leading cause of cancer-related deaths, progress is being made in disease etiology and pathogenesis, and intensive research is focused on developing optimal treatment approaches for patients. Considering the continuous progress being made in understanding PDAC pathogenesis and designing new therapies, it was considered timely to develop an up-to-date thematic issue of Advances in Cancer Research (ACR) focused on PDAC.\u003cbr\u003eIn this thematic issue, we have included ten review articles by experts that cover cancer disparities, PDAC pathobiology, the roles of the tumor microenvironment, tumor heterogeneity, PC stem cells, genetic and signaling events critical for PDAC pathogenesis, Immunotherapy and chemoresistance in PDAC, and different PDAC mouse models. 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These methods can prolong drug half-lives, improve bioavailability, optimize pharmacokinetics, and reduce medication dosing frequency.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChapters are written in a way that allows \u003c\/strong\u003ethe audience to not only become familiar with the most recent advancement in the field, but to better understand them by referring to various illustrations, figures, and informative tables. The contents cover an overview of colonic diseases, the cellular and molecular mechanisms involved, current and traditional therapeutic approaches, biomaterials, oral drug delivery methods, targeted drug delivery, nutraceuticals and herbal medicine approaches, prebiotics, probiotics and symbiotics, nanomedicine approaches, and the current status of clinical trials in the area.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003ci\u003eAdvanced Drug Delivery Systems for Colonic Disorders \u003c\/i\u003e\u003c\/strong\u003eis the perfect resources for researchers in pharma, biomaterials, and nutrition to familiarize themselves with new and upcoming therapeutic methods. Research physicians in GI can also benefit from reading this book for its clinical applications.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCovers recent perspectives and challenges towards the treatment of colonic disorders\u003c\/strong\u003e Provides insights into how advanced drug delivery systems can be effectively used for the management of various types of colonic disordersDiscusses drug delivery strategies to manage inflammatory bowel disease (chronic inflammation in the digestive tract), ulcerative colitis (inflammation and ulcers in colon), Crohn's disease, Colonic polyps, Shigellosis, Colon Bleeding or Hemorrhage, Diverticulosis and colon cancer\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003cbr\u003ePublisher: Elsevier Science; November 4, 2023\u003cbr\u003eLanguage: English \u003c\/p\u003e\n\u003cp\u003eISBN: 9780443140440\u003cbr\u003eISBN: 9780443140457\u003c\/p\u003e","brand":"ReadSpots - Medical Education","offers":[{"title":"Default Title","offer_id":52027680522533,"sku":null,"price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0969\/0189\/0341\/files\/9780443140440-9780443140457-1.jpg?v=1771939284"},{"product_id":"animal-models-of-disease-part-a-volume-185","title":"Animal Models of Disease: Part A, Volume 185","description":"\u003cp\u003e\u003cstrong\u003eAnimal Models of Disease, Part A, Volume 185\u003c\/strong\u003e in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including New mouse model to study aneurysm development, Mouse Model of Secondary Cystic Echinococcosis, Modelling childhood cancer in Drosophila, Analysis of immunohistomorphological changes in the colonic mucosa in a high-saturated fat and high-cholesterol fed streptozotocin\/nicotinamide diabetic rat model, Establishment of an orthotopic Glioblastoma mouse model for preclinical studies, Lateral Fluid Percussion Injury as a Model for Traumatic Brain Injury, Ovarian and colorectal peritoneal carcinomatosis in mouse models, and more.Other chapters cover Genetically engineered mouse model of hepatocellular carcinoma, Radiotherapy protocol in cancer mouse models, Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluation, Methodology for the induction of myocardial infarction and cardiac function evaluation, Behavioral assessment of fine socio-sexual olfactory cues detection in a mouse model of neurodegeneration, Heat shock and thermotolerance in Caenorhabditis elegans: an overview of laboratory techniques, and Using the model cestode Taenia crassiceps for the study of cysticercosis.\u003c\/p\u003e\n\u003cul class=\"a-unordered-list a-vertical\"\u003e\n\u003cli\u003eProvides the latest information on cancer research\u003c\/li\u003e\n\u003cli\u003eOffers outstanding and original reviews on a range of cancer research topics\u003c\/li\u003e\n\u003cli\u003eServes as an indispensable reference for researchers and students alike\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003cbr\u003eASIN ‏ : ‎ B0CTHRCY9K\u003cbr\u003ePublisher ‏ : ‎ Academic Press (March 29, 2024)\u003cbr\u003ePublication date ‏ : ‎ March 29, 2024\u003cbr\u003eLanguage ‏ : ‎ English\u003cbr\u003eSticky notes ‏ : ‎ On Kindle Scribe\u003c\/p\u003e","brand":"ReadSpots - Medical Education","offers":[{"title":"Default Title","offer_id":52027684421925,"sku":"RE0081-001","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0969\/0189\/0341\/files\/4109tZA0leL._SX342_SY445_QL70_FMwebp.webp?v=1771939503"},{"product_id":"bayesian-precision-medicine","title":"Bayesian Precision Medicine","description":"\u003cp\u003e\u003cstrong\u003eBayesian Precision Medicine \u003c\/strong\u003epresents modern Bayesian statistical models and methods for identifying treatments tailored to individual patients using their prognostic variables and predictive biomarkers. The process of evaluating and comparing treatments is explained and illustrated by practical examples, followed by a discussion of causal analysis and its relationship to statistical inference. A wide array of modern Bayesian clinical trial designs are presented, including applications to many oncology trials. The later chapters describe Bayesian nonparametric regression analyses of datasets arising from multistage chemotherapy for acute leukemia, allogeneic stem cell transplantation, and targeted agents for treating advanced breast cancer. Features: Describes the connection between causal analysis and statistical inference Reviews modern personalized Bayesian clinical trial designs for dose-finding, treatment screening, basket trials, enrichment, incorporating historical data, and confirmatory treatment comparison, illustrated by real-world applications Presents adaptive methods for clustering similar patient subgroups to improve efficiency Describes Bayesian nonparametric regression analyses of real-world datasets from oncology Provides pointers to software for implementation Bayesian Precision Medicine is primarily aimed at biostatisticians and medical researchers who desire to apply modern Bayesian methods to their own clinical trials and data analyses. It also might be used to teach a special topics course on precision medicine using a Bayesian approach to postgraduate biostatistics students. The main goal of the book is to show how Bayesian thinking can provide a practical scientific basis for tailoring treatments to individual patients.\u003cbr\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003cbr\u003ePublisher: Chapman \u0026amp; Hall;\u003cbr\u003eISBN: 9781040026717\u003cbr\u003eISBN: 9781032754468\u003cbr\u003eCopyright: 2024\u003c\/p\u003e","brand":"ReadSpots - Medical Education","offers":[{"title":"Default Title","offer_id":52027684618533,"sku":null,"price":89.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0969\/0189\/0341\/files\/9781040026717-9781003474258-9781040026663.jpg?v=1771939514"},{"product_id":"colorectal-cancer-disease-and-advanced-drug-delivery-strategies-12-month-access","title":"Colorectal Cancer: Disease and Advanced Drug Delivery Strategies","description":"\u003cp\u003e\u003cstrong\u003eColorectal Cancer: Disease and Advanced Drug Delivery Strategies\u003c\/strong\u003e examines the combined impact of basic clinical and medical treatments as well as recent advances in the field of colorectal cancer.With a strong focus towards colorectal cancer diagnosis, disease drug delivery, and diagnosis, the book also examines the Tumor microenvironment-responsive and site-specific nanoparticles for cancer theragnostics.In 16 chapters, Colorectal Cancer: Disease and Advanced Drug Delivery Strategies not only provides the opportunity to understand and diagnose the disease, but it also describes screening methods, drugs including nano- and immunotherapy, and gives insight into the role of nanoparticles, lipids, and biomarkers in colorectal cancer. 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This book directs researchers and clinicians how to better diagnose and treat colorectal cancer.\u003c\/p\u003e\n\u003cul class=\"a-unordered-list a-vertical\"\u003e\n\u003cli\u003eProvides a wealth of information on the latest research and developments in the science and treatment of colorectal cancer\u003c\/li\u003e\n\u003cli\u003eContains new and innovative ways to treat colorectal cancer\u003c\/li\u003e\n\u003cli\u003eReflects on basic clinical and medical methods and recent advances in colorectal cancer science\u003c\/li\u003e\n\u003cli\u003eGives specific details about how nanoparticles can be used to target cancer cells or cancer treatment\u003c\/li\u003e\n\u003cli\u003eCovers tumor microenvironment, their challenges, and opportunities in colorectal cancer research\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003cbr\u003eASIN ‏ : ‎ B0CP1366GB\u003cbr\u003ePublisher ‏ : ‎ Academic Press (November 19, 2023)\u003cbr\u003ePublication date ‏ : ‎ November 19, 2023\u003cbr\u003eLanguage ‏ : ‎ English\u003cbr\u003eScreen Reader ‏ : ‎ Supported\u003cbr\u003eSticky notes ‏ : ‎ On Kindle Scribe\u003c\/p\u003e","brand":"ReadSpots - Medical Education","offers":[{"title":"Default Title","offer_id":52027685503269,"sku":"RE0081-006","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0969\/0189\/0341\/files\/516Lz3mygxL._SX342_SY445_QL70_FMwebp.webp?v=1771939567"},{"product_id":"inflammation-resolution-and-chronic-diseases","title":"Inflammation Resolution and Chronic Diseases","description":"\u003cp\u003e\u003cstrong\u003eThis book provides recent advances in the understanding of the central processes in the resolution of inflammation\u003c\/strong\u003e. 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Chapters in this release cover Design and Discovery of Itaconate prodrugs for Alopecia Areata, Hydroxyl-Dendrimer Delivery System for Neurological Disease, Development of allosteric modulators of G protein-coupled receptors for Psychiatric Disease, Targeting the constitutively active ERK1\/2 signaling kinase for cancer, mRNA reprogramming of myeloid cells for tumor immunotherapy, Development of novel drugs targeting protein-protein interactions, and much more.\u003cbr\u003eAdditional sections cover Neuro-steroids and analogs for the treatment of epilepsy, Development of inhibitors of eukaryotic translation, Discovery\/development of antiviral, anticancer and\/or anti-inflammatory agents, Discovery of novel anti-infective agents, Targeting proliferating cell nuclear antigen (PCNA) for cancer, and Implementation and Evolution of Quantitative Systems Pharmacology to Patient Digital Twins and Biomimetic Twins.\u003cbr\u003eProvides recent examples of successful academic drug discovery projects in multiple disease areas, including oncology, immunology, neurology, and infectious diseases\u003cbr\u003ePresents diverse examples, including small molecule, biologic, and nanomedicine-based therapeutics\u003cbr\u003eDiscusses innovative artificial intelligence platforms utilized in academic drug discovery efforts\u003cbr\u003eProduct Details\u003cbr\u003ePublisher:\u003cbr\u003eAcademic Press;\u003cbr\u003eISBN:\u003cbr\u003e9780443293252\u003cbr\u003eISBN:\u003cbr\u003e9780443293245\u003cbr\u003eCopyright:\u003cbr\u003e2024\u003c\/p\u003e","brand":"ReadSpots - Medical Education","offers":[{"title":"Default Title","offer_id":52027690385701,"sku":null,"price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0969\/0189\/0341\/files\/9780443293252-1.jpg?v=1771939779"},{"product_id":"williams-textbook-of-endocrinology-15th-edition","title":"Williams Textbook of Endocrinology, 15th Edition","description":"\u003cp\u003eNow fully revised and updated, Williams Textbook of Endocrinology, 15th Edition, remains your go-to reference for authoritative content on the full spectrum of adult and pediatric endocrine system disorders. World-renowned authors and editors expertly bridge the gap between basic science and clinical information, keeping you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field.\u003cbr\u003ePresents current information in a highly illustrated, user-friendly format for quick reference.\u003cbr\u003eIncludes new chapters on Skeletal Regulation of Metabolism, Digitized Approaches to Diabetes Therapeutics, and MODY and Atypical Diabetes.\u003cbr\u003eReflects updated approaches to transgender medicine as well as new coverage of viral infections, including COVID-19.\u003cbr\u003eCovers hot topics such as personalized medicine; the latest methodologies and trends regarding cancer genomics, precision oncology, and cell biology; and updates in key areas such as adrenal dysfunction and diabetes.\u003cbr\u003eProvides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bone disorders, obesity and thyroid disease, as well as pituitary, gonadal, and adrenal disorders, and much more―all designed to help you provide optimal care to every patient.\u003cbr\u003eFeatures contributions from today’s thought leaders in endocrinology.\u003cbr\u003eContains a selected reading list and highlighted key references nominated by the editors.\u003cbr\u003eAn eBook version is included with purchase. 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